METABOLISM STUDIES BEFORE AND AFTER SPLENECTOMY IN CONGENITAL HEMOLYTIC ICTERUS

Photosensitive or congenital porphyria with hemolytic anemia. I. Clinical and fundamental studies before and after splenectomy.

Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia.

PURPOSE The purpose of this study was to define the hematologic response to total splenectomy (TS) or partial splenectomy (PS) in children with hereditary spherocytosis (HS) or sickle cell disease (SCD). METHODS The Splenectomy in Congenital Hemolytic Anemia (SICHA) consortium registry collected hematologic outcomes of children with CHA undergoing TS or PS to 1 year after surgery. Using rando...

Photosensitive or congenital porphyria with hemolytic anemia. II. Isotopic studies of porphyrin and hemoglobin metabolism.

N UNUSUAL OPPORTUNITY has l)een affordedi to carry out studlies of porphyrin and! hemoglobin metabolism with the aid of glycine containing N’5 in a 4 year old girl with manifestations of the photosensitive or congenital type of porphyria. Detailed descriptions of the clinical and! biochemical features of this patient are presented in paper I. At the time of the isotope studies anemia and spleno...

Recommendations for splenectomy in hereditary hemolytic anemias

Hereditary hemolytic anemias are a group of disorders including red cell membrane defects, red blood cells enzyme disorders, congenital dyserythropoietic anemias, thalassemia syndromes and haemoglobinopathies. As damaged red blood cells passing through the spleen red pulp are efficiently removed by splenic macrophages, splenectomy is one possible therapeutic approach to the management of severe...

Hemolytic anemia in myelogenous leukemia with splenectomy.

By ULFAR JONSSON, M.D., 0. C. HANSEN-PRUSS, M.D., AND R. W. RUNDLES, M.D. T HERE have been many reports in recent years of splenectomy for hemolytic anemia, thrombocytopenia, or pancytopenia resulting from vascular, infectious, or neoplastic involvement of the spleen.” 12, 13, 15 Hemolytic anemia has been observed in a few patients with leukemic splenomegaly) 6. 8. 13, 15 The leukemia has usual...